Divergent synthesis of unique trifluoromethyl alcohols through Lewis acid-catalyzed anti-Meinwald rearrangement

Key Points

• The study aims to develop a method for synthesizing trifluoromethyl alcohols through the anti-Meinwald rearrangement.
• Utilized Lewis acid catalysis to facilitate the transformation.
• Investigated the reaction mechanism and conditions for optimal yield.
• Compared outcomes between traditional Meinwald and anti-Meinwald rearrangements.
• Successfully synthesized unique trifluoromethyl alcohols in good yields.
• Showed a viable route for challenging anti-Meinwald rearrangement.
• Demonstrated the potential advantages over conventional methods.