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January 17, 2026Discover MaterialsOpen Access

Design, antibacterial activity, DNA interaction, anticancer and molecular docking analysis of novel bivalent metal chelates based on an no- donor schiff base ligand

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Authors

AEA. Z. El-SonbatiDamietta UniversityMEM. M. El-ZahedDamietta UniversityAEA. A. El-BindaryDamietta University

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Implication

Demonstrates the antibacterial and anticancer effects of bivalent metal chelates using a Schiff base ligand, suggesting their potential medical applications.

Key Points

  • The central aim is to synthesize bivalent metal chelates from a Schiff base ligand and evaluate their antibacterial and anticancer properties.
  • Synthesis of bivalent metal complexes via condensation of 2-amino-3-hydroxypyridine and 2,4-dihydroxybenzaldehyde.
  • Characterization using FTIR, UV-visible, 1H NMR, elemental analysis, and magnetic moment.
  • Assessment of antibacterial activity using MIC, MBC, and agar well diffusion tests.
  • Molecular docking of ligand and metal complexes with cancer targets to analyze binding affinities.
  • Metal complexes showed improved antibacterial activity compared to the Schiff base ligand, inhibiting various bacteria.
  • Inhibition zones for complex (3) ranged from 6 to 15 mm, and MIC values varied from 10 to 150 µg/ml.
  • Molecular docking revealed that metal coordination enhances hydrogen bonding and interaction profiles with cancer targets.

Cite This Study

El-Sonbati et al. (2026) studied this question.

synapsesocial.com/papers/696b2631d2a12237a93498b0https://doi.org/10.1007/s43939-025-00512-3
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