What question did this study set out to answer?

This research aims to investigate how maternal obesity influences the composition of human milk oligosaccharides (HMOs) and the gut microbiome in neonates.

January 17, 2026Gut MicrobesOpen Access

Maternal obesity alters human milk oligosaccharides content and correlates with early acquisition of late colonizers in the neonatal gut microbiome

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Authors

KCKarina Corona-CervantesInstituto Politécnico Nacional VUVíctor Hugo Urrutia-BacaTecnológico de Monterrey JGJuly S. Gámez-ValdezTecnológico de Monterrey

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Implication

Longitudinal study examines how maternal obesity affects milk oligosaccharides and infant gut microbiome, suggesting implications for early immune development.

Key Points

This research aims to investigate how maternal obesity influences the composition of human milk oligosaccharides (HMOs) and the gut microbiome in neonates.
Conducted a longitudinal study of Mexican mother-infant dyads.
Collected breastmilk samples from 97 mothers at multiple postpartum time points.
Analyzed milk samples using targeted and untargeted metabolomics.
Evaluated infant fecal microbiome composition using shotgun metagenomics.
Mothers with obesity had decreased concentrations of key HMOs shortly after birth.
Alterations in infant gut microbiota included fewer early colonizers (Enterobacteriaceae) and more late colonizers (Bifidobacterium, Lachnospiraceae).
Certain HMOs negatively correlated with late colonizer abundance and metabolic pathways were altered.

Cite This Study

Corona-Cervantes et al. (2026) studied this question.

synapsesocial.com/papers/696b2655d2a12237a93499a6 https://doi.org/10.1080/19490976.2025.2607043

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Implication

Longitudinal study examines how maternal obesity affects milk oligosaccharides and infant gut microbiome, suggesting implications for early immune development.

Maternal obesity alters human milk oligosaccharides content and correlates with early acquisition of late colonizers in the neonatal gut microbiome

Discussion

Member takes

Implication

Key Points

Cite This Study

Maternal obesity alters human milk oligosaccharides content and correlates with early acquisition of late colonizers in the neonatal gut microbiome

Discussion

Member takes

Implication

Key Points

Cite This Study

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