A novel catalyst enables efficient C–H alkylation of aryl ketones using alkyl halides, suggesting a cost-effective method for synthetic applications.
A new inexpensive cobalt( ii ) catalyst, [Co(η 1 -fluorenyl)-(µ 2 -OH)(MeOH) 2 ] 2 , enables the direct ortho -C–H alkylation of aryl ketones with stoichiometric quantities of diverse alkyl halides at room temperature using commercial-grade methanol.
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Nigade et al. (2026) studied this question.
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