What question did this study set out to answer?

The research aims to explore the role of enantioselective C–H functionalization in the synthesis of natural products.

January 18, 2026Open Access

Enantioselective C-H Functionalization: Logic and Applications in the Total Synthesis of Natural Products

PQPu‐Fan QianState Key Laboratory of Pollution Control and Resource Reuse BSBing-Feng ShiHangzhou Normal University

Key Points

The research aims to explore the role of enantioselective C–H functionalization in the synthesis of natural products.
Analyzed various enantioselective C-H functionalization techniques
Examined structural diversity of natural products
Explored applications in drug discovery and biomaterial development
Successful demonstration of enantioselective C-H functionalization in synthetic pathways
Increased efficiency in synthesizing diverse natural products
Highlighted significant bioactivities related to synthesized products

Abstract

Natural products, with their profound structural diversity and potent bioactivities, represent an invaluable source of inspiration for drug discovery and biomaterial development. The integration of enantioselective C–H functionalization into synthetic...

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