What question did this study set out to answer?

Investigate the coexistence of diabetic ketoacidosis and hyperosmolar hyperglycemic state in a pediatric case to highlight management complexities.

January 18, 2026Reports — Medical Cases Images and VideosOpen Access

Case Report of Overlap of Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State in a 5-Year-Old with New-Onset Type 1 Diabetes Mellitus: Diagnostic and Management Considerations

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Authors

FFFilippos FilippatosNational and Kapodistrian University of Athens GTGeorgios ThemelisNational and Kapodistrian University of Athens MDMaria DolianitiNational and Kapodistrian University of Athens

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Implication

Case report reveals diagnostic and management challenges in a 5-year-old with diabetic ketoacidosis and hyperosmolar hyperglycemic state overlap, indicating the need for vigilant therapy.

Key Points

Investigate the coexistence of diabetic ketoacidosis and hyperosmolar hyperglycemic state in a pediatric case to highlight management complexities.
Case presentation of a 5-year-old boy with symptoms of polyuria, polydipsia, and fatigue.
Laboratory evaluations confirmed diagnostic criteria for DKA/HHS overlap.
Fluid management was based on osmolality trajectory, with careful insulin administration.
Neurological and biochemical monitoring conducted hourly during treatment.
Patient recovered without complications such as cerebral edema or neurologic issues.
Positive IA-2 antibody and low C-peptide confirmed new-onset type 1 diabetes.
Fluids adjusted according to sodium and osmolality, with controlled insulin infusion ensuring gradual glucose decline.

Cite This Study

Filippatos et al. (2026) studied this question.

synapsesocial.com/papers/696c776ceb60fb80d1395a7b https://doi.org/10.3390/reports9010027

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Implication

Case report reveals diagnostic and management challenges in a 5-year-old with diabetic ketoacidosis and hyperosmolar hyperglycemic state overlap, indicating the need for vigilant therapy.

Case Report of Overlap of Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State in a 5-Year-Old with New-Onset Type 1 Diabetes Mellitus: Diagnostic and Management Considerations

Discussion

Member takes

Implication

Key Points

Cite This Study

Case Report of Overlap of Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State in a 5-Year-Old with New-Onset Type 1 Diabetes Mellitus: Diagnostic and Management Considerations

Discussion

Member takes

Implication

Key Points

Cite This Study

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