Abstract Myofibroma is a rare benign myofibroblastic tumour of spindle cell differentiation. Most commonly, myofibromas are observed in the context of a myofibromatosis disorder in children. Rarely, myofibroma can present as a solitary lesion in adults. We report a rare case of solitary myofibroma of the nasal vestibule which presented as a nonhealing ulcer on the anterior nasal septum. This is described in the context of a comprehensive literature review. Punch biopsies were obtained which revealed histological appearances in keeping with myofibroma. Following discussion at the regional head and neck and sarcoma multidisciplinary meetings, surgical excision was performed with staged reconstruction. To our knowledge, this is the first reported case of myofibroma arising from the anterior nasal septum and columella. This case highlights the importance of considering myofibroma as a differential diagnosis for nonhealing ulceration in this anatomical location.
Holland et al. (Wed,) studied this question.