Synthesis of CF 3 -Indene-1-ol Fused Pyridones Possessing Potent Anticancer Activities through C-H Activation-Initiated Cascade Annulation Under Redox-Neutral Conditions

Shasha Ye; Jiayi Zou; Xueying Yang; Haiyun Xu; Chunhua Ma; Xinying Zhang; Xuesen Fan

doi:10.1039/d5cc06846k

January 1, 2026Chemical Communications

Synthesis of CF 3 -Indene-1-ol Fused Pyridones Possessing Potent Anticancer Activities through C-H Activation-Initiated Cascade Annulation Under Redox-Neutral Conditions

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Key Points

The aim is to synthesize CF3-indene-1-ol fused pyridones and evaluate their anticancer activity.
Cascade reaction of N-methoxy acrylamides with CF3-ynones
Vinyl C-H activation to initiate synthesis
Conducted under redox-neutral conditions
Successful formation of CF3-indene-1-ol fused pyridones
Demonstrated potent anticancer activities
Effective under mild reaction conditions

Implication

Novel synthesis demonstrates potent anticancer effects in pyridone derivatives, indicating promising drug candidates.

Abstract

Presented herein is a novel synthesis of CF3-indene-1-ol fused pyridones through the cascade reaction of N-methoxy acrylamides with CF3-ynones. The formation of product involves an initial vinyl C-H activation of...

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Cite This Study

Ye et al. (2026) studied this question.

synapsesocial.com/papers/696c7791eb60fb80d1395ce1 https://doi.org/10.1039/d5cc06846k

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Synthesis of CF 3 -Indene-1-ol Fused Pyridones Possessing Potent Anticancer Activities through C-H Activation-Initiated Cascade Annulation Under Redox-Neutral Conditions

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of CF 3 -Indene-1-ol Fused Pyridones Possessing Potent Anticancer Activities through C-H Activation-Initiated Cascade Annulation Under Redox-Neutral Conditions

Key Points

Implication

Abstract

Discussion

Cite This Study

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