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The aim is to examine the solvent exposure of native cysteines in human Hsp90 to understand their role in protein dynamics.

Assessment of solvent exposure of native cysteines in human Hsp90 using thiol-reactive functional tags

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The aim is to examine the solvent exposure of native cysteines in human Hsp90 to understand their role in protein dynamics.
Utilized thiol-reactive functional tags to study cysteines in Hsp90.
Conducted experiments under physiological solution-phase conditions.
Analyzed solvent exposure using biochemical assays.
Identified specific cysteines with significant solvent exposure.
Demonstrated that cysteine exposure varies with conformational states of Hsp90.
Provided insights into the chaperone's structural dynamics under physiological conditions.

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This assessment reveals solvent exposure characteristics of cysteines in Hsp90, suggesting important insights into its structural dynamics.

Wang et al. (2025) studied this question.

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This assessment reveals solvent exposure characteristics of cysteines in Hsp90, suggesting important insights into its structural dynamics.