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The research aims to understand how the bone marrow microenvironment affects B-cell development after hematopoietic stem-cell transplantation.

January 18, 2026Blood AdvancesOpen Access

Acquired non-permissive BM microenvironment impairs HSCs proliferation and maintenance and B-cell development post-HSCT

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The research aims to understand how the bone marrow microenvironment affects B-cell development after hematopoietic stem-cell transplantation.
Analyzed longitudinal bone marrow samples from a patient and his twin with differing B-cell reconstitution outcomes.
Conducted in vitro modeling to assess HSC and B-cell survival and proliferation.
Performed bulk RNA-sequencing to evaluate changes in mesenchymal stromal cells.
Observed progressive loss of HSC proliferation and B-cell deficiency in the index patient's bone marrow.
Identified a selective block at the pre-BI cell stage and poor support from patient-derived MSCs for B-cell development.
Demonstrated that adding CXCL12 improved HSC survival and development in vitro.

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Observational study identifies impaired B-cell reconstitution in a patient post-HSCT, suggesting BM microenvironment's critical role.

Gier et al. (2026) studied this question.

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