Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Bone marrow microenvironment retinoic acid receptor signaling represses multipotential progenitor dependent B cell lymphopoiesis through secretion of resistin

View Full Paper
Ask AI
Bookmark
Share

Authors

NSNathan SalomonisJCJosé A. Cancelas

Discussion

Loading...

Member takes

Overview

Using RXR-deficient mice, this study demonstrates enhanced lymphopoiesis in hematopoietic stem cell transplantation, suggesting resistin modulation may improve immune recovery.

Key Points

  • To investigate the role of RXR signaling in B cell lymphopoiesis within the bone marrow microenvironment after HSCT.
  • Generated tamoxifen-inducible, BMA-specific RXRα/β deficient mice.
  • Conducted competitive repopulation assays to assess hematopoietic outcomes.
  • Performed single-cell RNA sequencing on LSK cells from RXR-deficient bone marrow.
  • Analyzed extracellular fluid secretome for inflammatory adipokines.
  • RXR deletion resulted in a 70% reduction of bone marrow adipocytes.
  • RXR-deficient mice showed a 13-fold increase in B cells post-transplant.
  • Resistin levels decreased by 80% in RXR-deficient bone marrow, correlating with improved lymphopoiesis.
  • Supplementation of resistin in RXR-deficient mice normalized B-lymphopoiesis.

Cite This Study

Salomonis et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d25ehttps://doi.org/10.1182/blood-2025-1405
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bone Marrow Adipokine Mediates Hematopoietic Regeneration and Stem Cell Fitness2025
  2. 2Bone marrow adipocytes fuel hematopoietic regeneration via fatty acid release2025
  3. 3Acquired non-permissive BM microenvironment impairs HSCs proliferation and maintenance and B-cell development post-HSCT2026
  4. 4P2rx7 in AML blasts orchestrates myeloid differentiation through T cell-mediated visfatin and lymphotoxin signaling2025
  5. 5Adrenergic signaling and hematopoietic stem cell function in the bone marrow niche rely on peri-arteriolar NADPH oxidase (NOX) and connexin gap junctions.2025