Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Bone marrow adipocytes fuel hematopoietic regeneration via fatty acid release

View Full Paper
Ask AI
Bookmark
Share

Authors

BSBo Shen

Discussion

Loading...

Member takes

Overview

Single-cell RNA sequencing reveals bone marrow adipocytes aid regeneration in hematopoietic stem cells, suggesting new therapeutic strategies.

Key Points

  • This research explores how bone marrow adipocytes influence hematopoietic regeneration via fatty acids.
  • Utilized single-cell RNA sequencing on murine bone marrow adipocytes.
  • Employed pharmacologic modulation with rosiglitazone and bisphenol A diglycidyl ether.
  • Analyzed hematopoietic stem/progenitor cell responses and regeneration post-bone marrow transplantation.
  • Developed a dual recombinase-mediated genetic strategy to target adipocyte-specific Pnpla2 deletion.
  • Rosiglitazone enhanced while bisphenol A diglycidyl ether inhibited hematopoietic regeneration.
  • Conditional deletion of Pnpla2 in adipocytes impaired fatty acid levels and hematopoietic regeneration.
  • Bone marrow adipocytes crucially support hematopoietic stem cell recovery.

Cite This Study

Bo Shen (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d753https://doi.org/10.1182/blood-2025-864
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bone Marrow Adipokine Mediates Hematopoietic Regeneration and Stem Cell Fitness2025
  2. 2Depletion of marrow adipo-CAR cells in mice enhances bone formation by activating bone morphogenetic protein receptor (BMPR) in pre-osteoblasts2025 · 4 citations
  3. 3Bone marrow microenvironment retinoic acid receptor signaling represses multipotential progenitor dependent B cell lymphopoiesis through secretion of resistin2025
  4. 4Reframing leukemia-niche interactions: the emerging role of the marrow adipocyte lineage2026
  5. 5Human Bone Marrow Adipocytes Block Granulopoiesis Through Neuropilin-1-Induced Granulocyte Colony-Stimulating Factor Inhibition2008 · 69 citations