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September 5, 2025Open Access

Bone Marrow Adipokine Mediates Hematopoietic Regeneration and Stem Cell Fitness

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Authors

PPParash PrasadADAngelo D’AlessandroYZYi Zheng

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Overview

Observational analysis reveals that adipokine resistin from bone marrow adipocytes regulates hematopoietic stem cells, highlighting a key mechanism for recovery after myeloablation.

Key Points

  • Resistin from bone marrow adipocytes enhances hematopoietic stem cell self-renewal and function, crucial for recovery.
  • Key evidence shows that loss of RXR in adiponectin-expressing cells leads to reduced Resistin, impairing hematopoietic regeneration.
  • This assessment identifies RXR signaling as pivotal for Resistin production in bone marrow adipocytes, affecting NF-kB activity.
  • Findings suggest that targeting adipokines like Resistin may support recovery strategies following myeloablative treatments.

Cite This Study

Prasad et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f3e6d6d5674bcd0337chttps://doi.org/10.1101/2025.08.28.672647
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bone marrow microenvironment retinoic acid receptor signaling represses multipotential progenitor dependent B cell lymphopoiesis through secretion of resistin2025
  2. 2Bone marrow adipocytes fuel hematopoietic regeneration via fatty acid release2025
  3. 3Bone marrow adipocytes: key players in vascular niches, aging, and disease2025
  4. 4Remodeling the Marrow Fat Niche: BMAT in Cancer Bone Metastases and Hematological Malignancies2026
  5. 5Hypoxia/HIF Signaling Negatively Regulates Bone Marrow Adiposity after Radiation Exposure2025