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September 12, 2025Open Access

Hypoxia/HIF Signaling Negatively Regulates Bone Marrow Adiposity after Radiation Exposure

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Authors

CJCheyenne A. JonesDuke UniversityWGWendi GuoDuke UniversityKGKiana A. GunnDuke University

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Implication

Experiment shows hypoxia/HIF signaling impacts marrow adiposity in response to radiation, indicating new avenues for cancer treatment.

Key Points

  • Radiation exposure rapidly increases marrow adipose tissue (MAT), impairing hematopoietic function.
  • Conditional knockout mice lacking HIF displayed enhanced MAT expansion following radiation treatment.
  • Investigation reveals uncharacterized stromal cells contribute to MAT formation in radiation-induced conditions.
  • Loss of HIF signaling in certain bone cells amplifies the risk of radiation-induced bone fragility.

Cite This Study

Jones et al. (2025) studied this question.

synapsesocial.com/papers/68d44f7b31b076d99fa56b7ahttps://doi.org/10.1101/2025.09.07.674016
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