August 7, 2025Frontiers in Cell and Developmental BiologyOpen Access

Bone marrow adipocytes: key players in vascular niches, aging, and disease

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Authors

YFYonggang FanHainan Medical University MEMai Kamal Abd El-Khalek YZYuheng ZhangUniversity of Electronic Science and Technology of China

Discussion

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Implication

Comprehensive review reveals how bone marrow adipocytes impact vascular niches and hematopoiesis, suggesting implications for aging and metabolic disorders.

Key Points

Bone marrow adipocytes are metabolically active and modulate their surrounding vascular niches.
Aging leads to an increase in adipogenesis in bone marrow, altering key adipokine and cytokine secretion.
Oxidative stress and chronic inflammation exacerbate the impact of adipocytes on marrow homeostasis.
Therapeutic strategies are discussed to modulate adipocyte pathways and their effects on diseases.

Cite This Study

Fan et al. (2025) studied this question.

synapsesocial.com/papers/689dfe88d61984b91e13b930 https://doi.org/10.3389/fcell.2025.1633801

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Implication

Comprehensive review reveals how bone marrow adipocytes impact vascular niches and hematopoiesis, suggesting implications for aging and metabolic disorders.

Bone marrow adipocytes: key players in vascular niches, aging, and disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Bone marrow adipocytes: key players in vascular niches, aging, and disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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Also Consider