Key result
Bone marrow adipocytes are distinct from white, brown, and beige adipocytes, constituting a distinct adipose depot that influences other marrow cells and whole-body metabolism via adipokines.
Key points are not available for this paper at this time.
Design
Review
May affect marrow and systemic metabolism; leaves open clinical translation pending interventional studies.
Adipocytes were identified in human bone marrow more than a century ago, yet until recently little has been known about their origin, development, function or interactions with other cells in the bone marrow. Little functional significance has been attributed to these cells, a paradigm that still persists today. However, we now know that marrow adipose tissue increases with age and in response to a variety of physiologic induction signals. Bone marrow adipocytes have recently been shown to influence other cell populations within the marrow and can affect whole body metabolism by the secretion of a defined set of adipokines. Recent research shows that marrow adipocytes are distinct from white, brown and beige adipocytes, indicating that the bone marrow is a distinct adipose depot. This review will highlight recent data regarding these areas and the interactions of marrow adipose tissue (MAT) with cells within and outside of the bone marrow.
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Horowitz et al. (2017) reported a review. Bone marrow adipocytes are distinct from white, brown, and beige adipocytes, constituting a distinct adipose depot that influences other marrow cells and whole-body metabolism via adipokines.
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