What question did this study set out to answer?

This review aims to present the various roles of the aryl hydrocarbon receptor (AHR) in physiology and pathology.

The aryl hydrocarbon receptor: structure, signaling, physiology and pathology

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This review explores AHR's roles in health and disease, highlighting its signaling mechanisms and therapeutic potential.

This review aims to present the various roles of the aryl hydrocarbon receptor (AHR) in physiology and pathology.
Reviewed six decades of AHR discoveries
Analyzed recent structural breakthroughs in ligand-binding
Examined AHR's role in immune regulation and tissue integrity
Discussed the impact of AHR ligands from toxins and metabolites
Highlighted potential therapeutic applications for AHR modulators
AHR functions as a crucial environmental and endogenous sensor
Identified diverse AHR ligands influencing activation pathways
Demonstrated involvement of AHR in cancer and autoimmune diseases
Suggests AHR as a promising target for therapeutic innovation
Emphasized the significance of AHR in maintaining physiological homeostasis.

Tête et al. (2026) studied this question.

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