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January 18, 2026JMIRx BioOpen Access

Machine Learning Ensemble Investigates Age in the Transcriptomic Response to Spaceflight in Murine Mammary Tissue: Observational Study

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Observational study reveals age impacts the molecular response of murine mammary tissue to spaceflight, suggesting tailored health strategies.

The study aims to characterize the molecular response of murine mammary tissue to spaceflight, focusing on the role of age in these responses.
Utilized transcriptomic data from 10 space-flown mice and 33 control mice from NASA's dataset.
Investigated two age groups: young and old mice.
Employed an ensemble of 4 machine learning classifiers for gene expression profile analysis.
Conducted pathway enrichment analysis on genes identified as predictive for age and condition.
Young mice showed enriched pathways related to lipid metabolism and inflammatory stress signaling.
All space-flown mice displayed adaptations in retinoid metabolism and signaling pathways relevant to carcinogenic risk.
Age-specific responses to spaceflight stress were significant, highlighting differing molecular mechanisms between age groups.

Casaletto et al. (2026) studied this question.

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Observational study reveals age impacts the molecular response of murine mammary tissue to spaceflight, suggesting tailored health strategies.