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The research explores how viral genes, particularly PEG10 and PEG11/RTL1, have influenced mammalian placentation and evolution.

January 18, 2026BiomoleculesOpen Access

Placenta-Driven Evolution: Viral Gene Acquisition and PEG10’s Essential Roles in Eutherian Placenta

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The research explores how viral genes, particularly PEG10 and PEG11/RTL1, have influenced mammalian placentation and evolution.
Examines evolutionary innovations in mammalian placentation
Analyzes the roles of PEG10 and PEG11/RTL1 in placental development
Investigates the relationship between viral gene acquisition and eutherian evolution
PEG10 is essential for the emergence of therian viviparity
PEG11/RTL1 contributes to differentiation between marsupial and eutherian placentas
Viral gene integration in the placenta is linked to eutherian genomic innovation

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Uncovers the role of viral genes in placenta evolution, suggesting implications for mammalian diversity.

Shiura et al. (2026) studied this question.

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