Solid-state Conformations of Pharmaceutical Polymorphs in Solution: Validation and Invalidation by NMR?

Kirthi Joshi; Shruti Sangwan; K. V. Jovan Jose; Vipin Agarwal; Ashwini Nangia

doi:10.1039/d5ce01120e

January 1, 2026CrystEngComm

Solid-state Conformations of Pharmaceutical Polymorphs in Solution: Validation and Invalidation by NMR?

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Key Points

The research aims to understand how different polymorphic forms of drugs influence their properties using NMR techniques.
Utilized NMR techniques to study polymorphic forms of pharmaceuticals.
Analyzed the solid-state conformations in solution for validation.
Comparative studies on multiple crystalline forms to assess differences.
Identified distinct physical and chemical properties among different polymorphs.
Validation of several polymorphs' conformations was successfully achieved using NMR techniques.
Certain polymorphs were invalidated as viable forms based on their properties.

Implication

Research uncovers the effects of drug crystalline forms on properties using NMR in pharmaceuticals, indicating significant relevance.

Abstract

Polymorphism is an important research area in the pharmaceutical industry because it provides understanding of how different crystalline forms of a drug can affect its physical and chemical properties, thereby...

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Cite This Study

Joshi et al. (2026) studied this question.

synapsesocial.com/papers/696c77f1eb60fb80d139631d https://doi.org/10.1039/d5ce01120e

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Solid-state Conformations of Pharmaceutical Polymorphs in Solution: Validation and Invalidation by NMR?

Key Points

Implication

Abstract

Discussion

Cite This Study

Solid-state Conformations of Pharmaceutical Polymorphs in Solution: Validation and Invalidation by NMR?

Key Points

Implication

Abstract

Discussion

Cite This Study

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