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January 18, 2026Clinical Nuclear Medicine

Prognostic Value of Lymphoscintigraphy and SPECT/CT After Vascularized Lymph Node Transfer in Lymphedema Patients

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Authors

JCJ. J. ChoSKS H KimHLHuisong LEE

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Overview

Evaluates treatment outcomes in lymphedema patients using lymphoscintigraphy and SPECT/CT, suggesting key prognostic insights.

Key Points

  • Evaluate the prognostic value of lymphoscintigraphy and SPECT/CT after vascularized lymph node transfer in lymphedema patients.
  • Included lymphedema patients who underwent VLNT from March 2019 to September 2023.
  • Performed lymphoscintigraphy 12 months post-surgery and SPECT/CT in a subset of patients.
  • Analyzed patient demographics, clinical stage, recipient site, lymph node flap type, and lymphoscintigraphic findings.
  • 54.4% of extremities showed positive radiotracer uptake in transferred lymph nodes.
  • Subjective symptom improvement was significantly higher in the uptake group (77.4% vs 38.5%, P = 0.003).
  • TLS grade improvement was greater in the uptake group (55.6% vs 9.1%, P < 0.001).
  • Cellulitis frequency was significantly decreased in patients with uptake (P = 0.010).
  • 70% of patients who had uptake achieved TLS grade improvement (P = 0.006).

Cite This Study

Cho et al. (2026) studied this question.

synapsesocial.com/papers/696c789ceb60fb80d1396b99https://doi.org/10.1097/rlu.0000000000006299
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ThP8.8 - Role of Lymphoscintigraphy in Lymphoedema2024
  2. 2Identifying Somatic Lymph Nodes for VLNT Using Technetium-99m Sulfur Colloid2025
  3. 3Analysis of different outcome parameters and quality of life after different techniques of free vascularized lymph node transfer2024 · 11 citations
  4. 4[Single-stage treatment of upper limb lymphedema following breast cancer surgery using superficial circumflex iliac artery perforator-based vascularized lymph node transfer combined with lymphaticovenular anastomosis and liposuction].2025 · 1 citations
  5. 5Impact of SPECT/CT lymphoscintigraphy-based radiotherapy planning for reducing incidental dose to arm draining lymph nodal region vs standard planning on lymphedema incidence in early breast cancer patients post BCS: A double blind randomized controlled trial.2026