What question did this study set out to answer?

This review aims to evaluate the advancements and challenges of CAR-T cell therapy in treating various diseases.

Engineering Immunity: Current Progress and Future Directions of CAR-T Cell Therapy

View Full Paper

Ask AI

Bookmark

Authors

This review explores CAR-T cell therapy's effectiveness in malignancies and autoimmune diseases, highlighting challenges and advancements.

This review aims to evaluate the advancements and challenges of CAR-T cell therapy in treating various diseases.
Examined CAR-T cell engineering advancements, particularly targeting CD19 and B cell maturation antigens.
Discussed strategies for enhancing CAR-T cell persistence and trafficking.
Reviewed applications in both hematologic malignancies and autoimmune diseases.
Remarkable remission rates achieved in hematologic malignancies with CD19-targeting CAR-T cells.
Challenges identified in applying CAR-T therapy to solid tumors due to antigen diversity and immunosuppressive TME.
Promising results from early studies of B cell-directed CAR-T cells in autoimmune diseases, such as systemic lupus erythematosus.

Sioud et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

This review explores CAR-T cell therapy's effectiveness in malignancies and autoimmune diseases, highlighting challenges and advancements.