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January 1, 2026Green Chemistry

Electrochemical C(sp2)-H Deuterodifluoromethylation of Quinoxalinones and 2H-Indazoles with CF2DSO2Na

Yuhang Ding Xin Liu Yanlin Wu Meichao Li Qian Wang

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Key Points

The study aims to efficiently introduce the deuterodifluoromethyl group into specific drug molecules.
Utilized electrochemical methods for the reaction
Focused on quinoxalinones and 2H-indazoles
Applied CF2DSO2Na as a reagent
Successfully achieved deuterodifluoromethylation of targeted compounds
Demonstrated the process's efficiency in a green chemistry context
Highlighted improved convenience for drug development

Implication

Research explores efficient deuterodifluoromethylation in drug molecules, suggesting a green chemistry implication.

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Cite This Study

Ding et al. (2026) studied this question.

synapsesocial.com/papers/696c789ceb60fb80d1396c72 https://doi.org/10.1039/d5gc05992e

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