Meta-analysis investigates hippocampal volume in depression, revealing contrasts between unipolar and bipolar disorders.
Hippocampal volume is reduced in patients with unipolar depression, maybe as a consequence of repeated periods of major depressive disorder. Bipolar patients did not seem to show a reduction in hippocampal volume, but this has been much less investigated.
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Videbech et al. (2004) studied this question.
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