What question did this study set out to answer?

To determine whether genetic background causes variations in native pial collateral circulation and whether these differences dictate the extent of stroke severity.

February 3, 2010Journal of Cerebral Blood Flow & MetabolismOpen Access

Wide Genetic Variation in the Native Pial Collateral Circulation is a Major Determinant of Variation in Severity of Stroke

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To determine whether genetic background causes variations in native pial collateral circulation and whether these differences dictate the extent of stroke severity.
Performed morphometric analyses of native collaterals in the unligated left hemisphere and remodeled collaterals in the ligated right hemisphere across 15 inbred mouse strains.
Assessed collateral vessel number, diameter, length, branching of penetrating arterioles, and arterial territories 6 days after permanent middle cerebral artery occlusion.
Native collateral vessel number varied 56-fold, diameter varied 3-fold, collateral length varied (P<0.001), and middle cerebral artery, anterior cerebral artery, and posterior cerebral artery territories varied by 42%, 56%, and 61%, respectively.
Infarct volume correlated inversely with collateral number (P<0.0001), diameter (P<0.0001), and penetrating arteriole count (P<0.05), while correlating directly with middle cerebral artery territory (P<0.05).
Relative collateral conductance combined with middle cerebral artery territory strongly predicted infarct volume (P<0.0001), and outward collateral remodeling varied approximately 3-fold across strains.

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Implication

Preclinical study reveals wide genetic variation in native pial collateral circulation strongly predicts stroke infarct volume in mice, indicating innate vascular anatomy dictates stroke severity.

Cite This Study

Zhang et al. (2010) studied this question.

synapsesocial.com/papers/696d734c50a360e9ca1198b9 https://doi.org/10.1038/jcbfm.2010.10

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Implication

Preclinical study reveals wide genetic variation in native pial collateral circulation strongly predicts stroke infarct volume in mice, indicating innate vascular anatomy dictates stroke severity.

Wide Genetic Variation in the Native Pial Collateral Circulation is a Major Determinant of Variation in Severity of Stroke

Key Points

Discussion

Implication

Cite This Study

Wide Genetic Variation in the Native Pial Collateral Circulation is a Major Determinant of Variation in Severity of Stroke

Key Points

Discussion

Implication

Cite This Study

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