Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 2003StrokeOpen Access

Dipyridamole Enhances NO/cGMP-Mediated Vasodilator-Stimulated Phosphoprotein Phosphorylation and Signaling in Human Platelets

View Full Paper
Ask AI
Bookmark
Share

Key result

Therapeutically relevant concentrations of dipyridamole amplified NO/cGMP-mediated VASP phosphorylation in human platelets, enhancing platelet inhibition ex vivo.

Why the study?

Does dipyridamole enhance NO/cGMP-mediated VASP phosphorylation and signaling in human platelets?

Population

Human platelets (in vitro) and healthy volunteers (ex vivo)

Comparison

Dipyridamole vs Vehicle or baseline (absence of dipyridamole)

Design

Preclinical

Follow-up

3 hours

Authors

BABarsom AktasIndiana University School of MedicineAUAndrea L. UtzVanderbilt UniversityPHPetra Hoenig-LiedlUniversity of Würzburg

Discussion

Loading...

Member takes

Implication

Supports mechanistic role of dipyridamole in NO-mediated platelet inhibition; leaves open whether this improves stroke outcomes.

Structured PICO

Does dipyridamole enhance NO/cGMP-mediated VASP phosphorylation and signaling in human platelets?

P
Population
Human platelets (in vitro) and healthy volunteers (ex vivo)
I
Intervention
Dipyridamole (in vitro 3.5 μmol/L; ex vivo 200 mg extended-release capsule)
C
Comparator
Vehicle or baseline (absence of dipyridamole)
O
Outcome
Phosphorylation of vasodilator-stimulated phosphoprotein (VASP)surrogate

Dipyridamole enhances platelet inhibition by amplifying NO/cGMP-mediated signaling, providing a mechanistic explanation for its clinical efficacy in stroke prevention.

Cite This Study

Aktas et al. (2003) studied this question. Therapeutically relevant concentrations of dipyridamole amplified NO/cGMP-mediated VASP phosphorylation in human platelets, enhancing platelet inhibition ex vivo.

synapsesocial.com/papers/696d734c50a360e9ca1198behttps://doi.org/10.1161/01.str.0000056527.34434.59

Topics

Dual antiplatelet therapy
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide1987 · 1,174 citations
  2. 2Flow Cytometry Analysis of Intracellular VASP Phosphorylation for the Assessment of Activating and Inhibitory Signal Transduction Pathways in Human Platelets1999 · 300 citations
  3. 3cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.1994 · 470 citations
  4. 4Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling2002 · 679 citations