January 1, 1999Thrombosis and Haemostasis

Flow Cytometry Analysis of Intracellular VASP Phosphorylation for the Assessment of Activating and Inhibitory Signal Transduction Pathways in Human Platelets

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Population

Human platelets

Authors

USUlrike R. SchwarzUniversity of Würzburg JGJörg GeigerHarvard University UWUlrich Walter

Discussion

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Implication

May aid lab assessment of P2Y12 inhibition; leaves open clinical monitoring utility pending validation.

Structured PICO

Population

Human platelets

Intervention

Flow cytometry-based method using a phosphorylation-specific antibody for VASP

Outcome

Quantification of the phosphorylation state of a specific intracellular platelet protein (VASP)surrogate

This novel flow cytometry assay enables rapid quantification of platelet VASP phosphorylation, providing a tool to monitor the efficacy of antiplatelet therapies like clopidogrel and ticlopidine.

Cite This Study

Schwarz et al. (1999) studied this question.

synapsesocial.com/papers/6a209b5be15907458191ccc1 https://doi.org/10.1055/s-0037-1614344

Topics

Dual antiplatelet therapy

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Flow Cytometry Analysis of Intracellular VASP Phosphorylation for the Assessment of Activating and Inhibitory Signal Transduction Pathways in Human Platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Flow Cytometry Analysis of Intracellular VASP Phosphorylation for the Assessment of Activating and Inhibitory Signal Transduction Pathways in Human Platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider