Key result
Asymptomatic moderate-to-severe AS shows ~4 ml/m2 increase in indexed LV volume over one year.
Why the study?
Aortic stenosis is characterized by a long and variable asymptomatic course, and the progression of adverse remodeling during this phase needed assessment using cardiovascular MRI.
Population
43 asymptomatic patients with moderate to severe AS
Comparison
Cardiac MRI at baseline vs repeat cardiac MRI at 12 months
Design
Prospective multi-centre observational study
Follow-up
12 months
Authors
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Adverse remodeling progressed over 12 months in asymptomatic moderate-severe AS; leaves open whether serial CMR should guide earlier intervention.
Observational (n=43)
Yes
Absolute Event Rate: 94.5% vs 90.7%
p-value: p=0.007
Asymptomatic patients with moderate to severe aortic stenosis demonstrate significant progression in adverse cardiac remodeling and focal myocardial fibrosis over 12 months, suggesting a potential need for earlier intervention.
Singh et al. (2020) conducted an observational in Asymptomatic Aortic Stenosis (n=43). Cardiovascular Magnetic Resonance Imaging (MRI) was evaluated on Progression of cardiac remodeling measured by indexed left ventricular (LV) and left atrial volumes and NT-proBNP levels (p=0.007). Cardiovascular magnetic resonance imaging indicated a significant increase in indexed left ventricular volume from 90.7 to 94.5 ml/m2 over 12 months in asymptomatic patients with moderate to severe aortic stenosis.
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