Can minimal residual disease be used to tailor therapy duration for chronic lymphocytic leukemia patients?

While fixed-duration therapy simplifies treatment, MRD-guided approaches offer a more individualized strategy that may optimize outcomes while minimizing overtreatment. Ongoing trials will further define the role of MRD-adapted therapy duration in first-line CLL treatment. Overall, MRD is a powerful tool to move beyond one-size-fits-all regimens and may become integral in personalizing CLL management across diverse therapeutic regimens.