Feasibility of neurite oriented diffusion and density imaging in thigh skeletal muscle of volunteers with knee pain: relationship with proton density fat fraction: a cross-sectional study

Yiou Wang; Ziru Qiu; J Liu; Yan-Jun Chen; Xiaohe Zhang; Ruoxing Liao; Dong Han; Xiaohe Zhang; Xiaohe Zhang

doi:10.1186/s12880-025-02127-9

January 17, 2026BMC Medical ImagingOpen Access

Feasibility of neurite oriented diffusion and density imaging in thigh skeletal muscle of volunteers with knee pain: relationship with proton density fat fraction: a cross-sectional study

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Key Points

This research aims to evaluate the microstructural differences in thigh skeletal muscle of volunteers with knee pain compared to asymptomatic individuals.
Used neurite oriented diffusion and density imaging techniques.
Examined thigh skeletal muscle microstructure in volunteers with and without knee pain.
Analyzed the relationship between muscle microstructure and proton density fat fraction.
Detected significant microstructural differences in the thigh muscle of volunteers with knee pain.
Found a strong relationship between muscle microstructure and intramuscular fat infiltration.

Implication

Cross-sectional study shows microstructure differences in thigh muscle related to fat infiltration in knee pain volunteers, suggesting diagnostic potential.

Abstract

Microstructure differences in thigh skeletal myofibrils were detected in volunteers with knee pain compared to asymptomatic volunteers, and were more closely related to intramuscular fat infiltration.

Discussion

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/696f1a469e64f732b51ee8ae https://doi.org/10.1186/s12880-025-02127-9

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Feasibility of neurite oriented diffusion and density imaging in thigh skeletal muscle of volunteers with knee pain: relationship with proton density fat fraction: a cross-sectional study

Key Points

Implication

Abstract

Discussion

Cite This Study

Feasibility of neurite oriented diffusion and density imaging in thigh skeletal muscle of volunteers with knee pain: relationship with proton density fat fraction: a cross-sectional study

Key Points

Implication

Abstract

Discussion

Cite This Study

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