Demonstrates a method for detecting streptomycin in pharmaceutical formulations and human plasma, highlighting its potential for routine quality control.
Key Points
The aim is to develop a sensitive method for quantifying streptomycin in different matrices, including pharmaceuticals and human plasma.
Developed a spectrofluorimetric method using fluorescamine as a probe.
Evaluated detection sensitivity using various concentrations of streptomycin.
Applied the method to pharmaceutical vials and spiked human plasma samples.
Achieved a detection limit of 8.3 ng/mL and quantitation limit of 25.2 ng/mL.
Demonstrated high precision with RSD < 2% and accuracy with recoveries between 98.1–101.3%.
Successfully detected streptomycin in commercial vials with a recovery of 99.7 ± 0.8%.