Angiogenic Effects Of Copper Nanoparticles On Blood Vessel Distribution, Vegf, Ctgf, Tgf- β3, And Type I Collagen Expression In The Healing Of Radial Meniscus Tears In The Avascular Zone

Key Points

• To investigate the angiogenic effects of copper nanoparticles on vascularization and specific protein expressions during the healing of meniscus tears.
• Utilized copper nanoparticles as an intervention to promote healing.
• Examined the expression of VEGF, CTGF, TGF-β3, and Type I Collagen.
• Assessed blood vessel distribution in the avascular zone of radial meniscus tears.
• Copper nanoparticles enhanced blood vessel distribution significantly.
• Increased expression levels of VEGF and CTGF were observed.
• TGF-β3 and Type I Collagen expressions were also positively influenced during healing.