Abstract Background: Prelabour rupture of membranes (PROM) complicates 8–10% of pregnancies and increases infection risk with delayed labour. Early induction is preferred to reduce complications. Misoprostol and oxytocin are commonly used agents. This study compares their efficacy and safety for labour induction in term PROM to determine the more effective and safer option. Aim: To compare efficacy and safety of oral misoprostol with intravenous oxytocin for induction of labour in women with premature rupture of membrane. Result: Both groups showed comparable demographic and obstetric profiles. Misoprostol achieved faster induction-to-delivery (p=0.02) with 86.7% vaginal deliveries versus 80% in Oxytocin. Neonatal outcomes, including mean birth weight (2.91 kg vs 2.86 kg) and APGAR scores, were similar, with no significant maternal complications. Method: This randomized study at SMS Medical College, Jaipur, included women with term PROM meeting inclusion criteria. Participants were randomly assigned to oral Misoprostol (25 µg every 3 hours, max five doses) or intravenous Oxytocin (5 IU/500 mL Ringer’s lactate). Detailed clinical evaluation, ultrasound, and laboratory investigations were conducted before induction. Conclusion: The study concludes that both oral Misoprostol and intravenous Oxytocin are safe and effective for labour induction in nulliparous women with term PROM. Misoprostol showed a shorter induction-to-delivery interval and faster labour progression. However, due to the limited sample size, larger multicentric studies are recommended to validate these findings.
International Journal of Medical Science and Advanced Clinical Research (IJMACR) (Sun,) studied this question.