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This cohort study finds no significant advantage of high-dose aspirin over low-dose aspirin in children with Kawasaki Disease, suggesting alternatives.
In a retrospective single-center cohort study of 460 children with Kawasaki Disease, initial treatment with low-dose aspirin and IVIG resulted in similar coronary artery outcomes and IVIG retreatment rates compared to high-dose aspirin and IVIG. These findings support consideration of low-dose aspirin for the management of acute-phase Kawasaki Disease.
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Thadani et al. (2026) studied this question.
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