The Pre-MYO project is a prospective, multicenter observational registry designed to enroll 3,000 patients with suspected myocarditis to investigate novel diagnostic and prognostic biomarkers.
Observational (n=3,000)
Yes
The Pre-MYO project is a prospective, multicenter registry designed to enroll 3,000 patients to investigate precision medicine approaches, including novel biomarkers, for the diagnosis and management of myocarditis.
Abstract Aims Myocarditis is an inflammatory disease characterized by a wide spectrum of clinical presentations, which complicates its diagnosis and management. The Precision Biomarkers for Diagnosis and Management of Myocardial Inflammatory Diseases (Pre-MYO) project aims to address three major gaps: 1) the limited knowledge regarding the epidemiology, clinical management and prognosis; 2) the absence of specific and widely accessible biomarkers able to provide an early diagnosis (precision medicine); 3) the lack of biomarkers of susceptibility to myocarditis, including risk of recurrence and disease severity (personalized medicine). Methods Pre-MYO is a prospective, observational and multicenter nationwide project designed to enroll 3,000 patients with suspected myocarditis or inflammatory cardiomyopathy based on clinical findings. The registry includes extensive clinical characterization and long-term follow-up, including biobanks of blood samples, DNA, and cardiac magnetic resonance imaging (CMR). The platform will enable the investigation and validation of novel diagnostic and prognostic biomarkers, including the candidate hsa-RNA-Chr8:96, and the development of clinical trials. Predisposition studies will be conducted to investigate environmental and immune factors, genetic mutations, and acquired variants—including methylation analyses—that contribute to individual predisposition and risk. Conclusions The Pre-MYO project will establish a collaborative research framework aimed at improving the understanding and clinical management of myocarditis by integrating precision and personalized medicine approaches.
Rubio et al. (Wed,) conducted a observational in Suspected myocarditis or inflammatory cardiomyopathy (n=3,000). Pre-MYO registry was evaluated. The Pre-MYO project is a prospective, multicenter observational registry designed to enroll 3,000 patients with suspected myocarditis to investigate novel diagnostic and prognostic biomarkers.