What question did this study set out to answer?

The study aims to examine the presentation and treatment response of ankylosing spondylitis patients.

January 20, 20260 citationsOpen Access

Presentation of A Case Series of ankylosing spondylitis at a private hospital in Andhra Pradesh and their response to various treatment modalities

I(International Journal of Medical Science and Advanced Clinical Research (IJMACR)

Key Points

The study aims to examine the presentation and treatment response of ankylosing spondylitis patients.
Analyzed 8 patients diagnosed with ankylosing spondylitis under 40 years old.
Included assessments of morning stiffness, HLA-B27 positivity, and inflammatory markers like ESR and CRP.
Evaluated the effectiveness of ASAS criteria for diagnosis and various treatment modalities.
All patients were HLA-B27 positive and showed elevated ESR and CRP levels.
Early application of ASAS criteria facilitated timely diagnosis and improved management of symptoms.
Incorporating platelet-rich plasma and intra-articular steroid therapy provided better pain relief compared to NSAIDs and DMARDs alone.

Abstract

Abstract The term, ‘ankylosing’ has been derived from the Greek word, ‘ankylos’, which means stiffening of a joint, while ‘spondylos’ means vertebra. The aetiology of ankylosing spondylitis is unknown, and it primarily affects the axial skeleton. Familial incidence is common. Approximately 90-95% of the patients with ankylosing spondylitis are positive for the human leukocyte antigen B27 (HLA-B27) assay. The age of onset is second or third decade of life and males are affected two to three times more than females. The Assessment of Spondyloarthritis International Society (ASAS) classification criteria for axial spondyloarthritis (axSpA) developed in 2009 was a major step forward, since the 1984 modified New York (mNY) criteria for classification of ankylosing spondylitis (AS) were too insensitive to identify patients with early signs of axial inflammation. In this study, we have studied 8 patients, all of them below 40years, all of them presented with morning stiffness of more than 30minutes, all of them are HLA B27 positive, all of them have elevated ESR and CRP. Absence of sacroilitis on imaging at presentation delayed their diagnosis at different centers and few of them got diagnosed as rheumatoid arthritis. Conclusion: Application of ASAS criteria helps in early diagnosis of ankylosing spondylitis and prevents morbidity. Also by adding Platelet rich plasma (PRP) or intraarticular steroid (IA) therapy helps in relief of pain which is not controlled by NSAIDS and DMARDS alone.

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