This analysis compares different serum-free light chain assays for diagnosing multiple myeloma, suggesting implications for clinical decisions.
KHB, as a sFLC detection method based on polyclonal antibodies and immunoturbidimetric principles, has a good correlation between its detection results and freelite and N Latex. The absolute difference in sFLC results among the three assays increased with increasing sFLC concentration, and selecting the same cutoff value for iFLC/niFLC may lead to inconsistent clinical treatment decisions in some patients.
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Cui et al. (2026) studied this question.
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