What question did this study set out to answer?

To assess the impact of amantadine and chlorphenamine on behavioral abnormalities in older patients with renal decline.

January 20, 2026Journal of Medical Case Reports0 citationsOpen Access

Behavioral abnormalities in older patients with chronic renal function decline following administration of compound paracetamol and amantadine hydrochloride capsules

YDYu DongQuzhou City People's Hospital JCJufen ChengQuzhou City People's Hospital ZQZhixiong QiuQuzhou City People's Hospital

Key Points

To assess the impact of amantadine and chlorphenamine on behavioral abnormalities in older patients with renal decline.
Evaluated the effects of amantadine and chlorphenamine on older patients with chronic renal dysfunction.
Monitored behavioral changes and safety concerns in the population after medication administration.
Analyzed patient responses to determine risks versus benefits of drug use.
Increased toxicity of amantadine was observed in older patients with renal insufficiency.
Chlorphenamine use correlated with higher risks of delirium in this demographic.
Prompt discontinuation and hydration were recommended to mitigate adverse reactions.

Abstract

The central toxicity of amantadine is significantly enhanced in older patients with renal insufficiency, and chlorphenamine may increase the risk of delirium. The risks associated with using this medication in older patients suffering from the common cold far outweigh the benefits, warranting cautious use in clinical practice; adverse reactions should be managed with prompt discontinuation of the medication and hydration to facilitate drug clearance. This study provides crucial warnings about medication safety in the older population.

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Cite This Study

Dong et al. (Sat,) studied this question.

synapsesocial.com/papers/696f1b189e64f732b51ef304 https://doi.org/https://doi.org/10.1186/s13256-025-05811-0

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