May 1, 2017Journal of Psychiatric Practice

The Role of Amantadine Withdrawal in 3 Cases of Treatment-Refractory Altered Mental Status

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Why the study?

Does amantadine withdrawal cause treatment-refractory altered mental status in medically complex patients?

Population

3 medically complex patients with altered mental status

Design

Case_series

Authors

LFLeah Fryml KWKristen R. Williams CPChristopher PelicMedical University of South Carolina

Discussion

Member takes

Implication

Supports cautious amantadine tapering to avert withdrawal; leaves open broader dopaminergic risks in observational data.

Structured PICO

Does amantadine withdrawal cause treatment-refractory altered mental status in medically complex patients?

Population

3 medically complex patients with altered mental status (a 64-year-old man with Parkinson disease, a 75-year-old depressed patient, and a 57-year-old patient with schizoaffective disorder)

Intervention

Amantadine withdrawal/discontinuation and subsequent reintroduction or electroconvulsive therapy

Outcome

Clinical presentation and resolution of altered mental status, delirium, or neuroleptic malignant syndrome

Amantadine withdrawal should be recognized as a potential cause of severe altered mental status, delirium, catatonia, or neuroleptic malignant syndrome in medically complex patients.

Cite This Study

Fryml et al. (2017) studied this question.

synapsesocial.com/papers/6a72dcd88084ee2b64303f21 https://doi.org/10.1097/pra.0000000000000237

View Full Paper

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The Role of Amantadine Withdrawal in 3 Cases of Treatment-Refractory Altered Mental Status

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Role of Amantadine Withdrawal in 3 Cases of Treatment-Refractory Altered Mental Status

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider