Why the study?
Does abrupt withdrawal of amantadine precipitate neuroleptic-induced catatonia in patients on neuroleptic therapy?
Population
1 patient on neuroleptic therapy
Design
Case_report
Authors
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May warrant gradual amantadine taper with neuroleptics; hypothesis-generating for shared dopaminergic mechanisms with NMS.
Does abrupt withdrawal of amantadine precipitate neuroleptic-induced catatonia in patients on neuroleptic therapy?
Abrupt withdrawal of amantadine during neuroleptic therapy can precipitate neuroleptic-induced catatonia, suggesting a shared dopaminergic mechanism with neuroleptic malignant syndrome.
Brown et al. (1986) studied this question.
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