Key result
Abrupt and simultaneous withdrawal of long-acting neuroleptics and anticholinergic medications was associated with the development of neuroleptic malignant syndrome in a young schizophrenic patient.
Why the study?
Does abrupt withdrawal of long-acting neuroleptic combined with anticholinergic treatment cause Neuroleptic Malignant Syndrome in schizophrenic patients?
Case Report (n=1)
Does abrupt withdrawal of long-acting neuroleptic combined with anticholinergic treatment cause Neuroleptic Malignant Syndrome in schizophrenic patients?
Simultaneous withdrawal of both anticholinergic and neuroleptic medications, mainly long-acting neuroleptics, seems to be a risk factor for Neuroleptic Malignant Syndrome.
Abrupt neuroleptic/anticholinergic withdrawal may precipitate NMS; leaves open optimal tapering and treatment strategies.
Neuroleptic malignant syndrome (NMS) is a severe side-effect of neuroleptic treatment. It is usually related to hypodopaminergic activity. A young schizophrenic patient who developed a typical episode of NMS during abrupt withdrawal of long-acting neuroleptic combined with anticholinergic treatment is described. NMS appeared following combined neuroleptic/ anticholinergic withdrawal and responded to procyclidine administration. The appearance of NMS after discontinuation of antidopaminergic treatment seems to be in conflict with the hypodopaminergic theory of this adverse effect. It is suggested that simultaneous withdrawal of both anticholinergic and neuroleptic medications, mainly long-acting neuroleptics, seems to be a risk factor for NMS.
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Спивак et al. (1996) conducted a case report in Schizophrenia and Neuroleptic Malignant Syndrome (n=1). Abrupt withdrawal of long-acting neuroleptic combined with anticholinergic treatment was evaluated on Development of neuroleptic malignant syndrome. Abrupt and simultaneous withdrawal of long-acting neuroleptics and anticholinergic medications was associated with the development of neuroleptic malignant syndrome in a young schizophrenic patient.
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