Key result
Amantadine plus diazepam resolves neuroleptic-induced catatonia in a single case report.
Case Report (n=1)
The case highlights the overlap between neuroleptic-induced catatonia and mild neuroleptic malignant syndrome, supporting the concept of a 'neuroleptic toxicity spectrum'.
May support amantadine-diazepam in neuroleptic catatonia; leaves open need for controlled trials.
Neuroleptic-induced catatonia (NIC) and milder neuroleptic malignant syndrome (NMS) share parkinsonian features, catatonic symptoms, mild fever, and have been described in patients receiving antipsychotic agents. We report the case of a patient with a schizophreniform disorder and a mild mental retardation who developed a condition which can be diagnosed either as NIC or as a mild form of NMS and has been treated successfully with a combination of amantadine (600 mg/day) and diazepam (30 mg/day). The overlapping between NIC and mild NMS cases might lead to an overestimation of the incidence of current NMS and reinforces the view of the existence of a 'neuroleptic toxicity spectrum'.
No takes yet. Share an insight, caveat, or question.
Kontaxakis et al. (2008) conducted a case report in Neuroleptic-induced catatonia or mild neuroleptic malignant syndrome (n=1). Amantadine and diazepam was evaluated on Treatment success. A patient with neuroleptic-induced catatonia or mild neuroleptic malignant syndrome was successfully treated with a combination of amantadine (600 mg/day) and diazepam (30 mg/day).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: