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July 1, 2000CNS Spectrums

An Analysis of 17 Catatonic Patients Diagnosed With Neuroleptic Malignant Syndrome

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Why the study?

Does neuroleptic administration precipitate neuroleptic malignant syndrome in patients with pre-existing catatonia?

Population

17 consecutive cases of neuroleptic malignant syndrome, 8 males and 9 females, age 18-65 years, all…

Design

Case_series

Authors

DWDenise WhiteUniversity of Cape Town

Discussion

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Overview

May warrant neuroleptic caution in catatonia; leaves open a possible unitary catatonia-NMS spectrum.

Structured PICO

Does neuroleptic administration precipitate neuroleptic malignant syndrome in patients with pre-existing catatonia?

P
Population
17 consecutive cases of neuroleptic malignant syndrome (NMS), 8 males and 9 females, age 18-65 years, all exhibiting features of catatonia prior to neuroleptic exposure.
I
Intervention
Neuroleptic administration (single dose in 9 cases)
O
Outcome
Development of neuroleptic malignant syndrome (NMS) features (febrile, rigid, obtunded state, autonomic dysfunction, raised creatine phosphokinase)safety

Catatonia appears to be a predisposing prodromal state for neuroleptic malignant syndrome, suggesting they may be part of a unitary pathophysiological disorder.

Cite This Study

Denise White (2000) studied this question.

synapsesocial.com/papers/6a98df137b594f460dbd3dbfhttps://doi.org/10.1017/s1092852900013419
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Catatonia and Neuroleptic Malignant Syndrome2012 · 43 citations
  2. 2Catatonia in a Possible Case of Moderate Neuroleptic Malignant Syndrome: A Case Report2025
  3. 3Catatonia versus neuroleptic malignant syndrome: the diagnostic dilemma and treatment2014 · 9 citations
  4. 4Catatonia: Harbinger of the Neuroleptic Malignant Syndrome1991 · 196 citations
  5. 5Catatonia and the Neuroleptic Malignant Syndrome – a Single Entity?1992 · 134 citations