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December 29, 2012The Journal of Nervous and Mental Disease

Catatonia and Neuroleptic Malignant Syndrome

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Key result

ECT plus benzodiazepines safely resolves neuroleptic malignant syndrome and residual catatonia in four bipolar patients.

  • n=4

Population

4 bipolar patients who developed neuroleptic malignant syndrome (NMS) after antipsychotic treatment

Design

Case_series

Authors

FLFederica LuchiniUniversity of PisaLLLorenzo LattanziAzienda Ospedaliera Universitaria PisanaNBNatalia BartolommeiUniversity of Pisa

Discussion

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Overview

Supports consideration in refractory cases; leaves open need for controlled trials before practice change.

Study Design

Type

Case Report (n=4)

Structured PICO

P
Population
4 bipolar patients who developed neuroleptic malignant syndrome after antipsychotic treatment.
I
Intervention
Electroconvulsive therapy (ECT) in combination with benzodiazepines (BDZ) and supportive therapy
O
Outcome
Resolution of clinical picture (NMS and residual catatonia)

ECT combined with benzodiazepines appears effective and safe for treating neuroleptic malignant syndrome and residual catatonia in bipolar patients.

Cite This Study

Luchini et al. (2012) conducted a case report in Neuroleptic malignant syndrome and catatonia in bipolar disorder (n=4). Electroconvulsive therapy (ECT) in combination with benzodiazepines (BDZ) was evaluated on Resolution of clinical picture. Electroconvulsive therapy in combination with benzodiazepines was effective and safe in resolving neuroleptic malignant syndrome and residual catatonia in four bipolar patients.

synapsesocial.com/papers/6aa4778e27d245a4842bc36ehttps://doi.org/10.1097/nmd.0b013e31827ab24b
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An Analysis of 17 Catatonic Patients Diagnosed With Neuroleptic Malignant Syndrome2000 · 43 citations
  2. 2Catatonia versus neuroleptic malignant syndrome: the diagnostic dilemma and treatment2014 · 9 citations
  3. 3Catatonia in a Possible Case of Moderate Neuroleptic Malignant Syndrome: A Case Report2025
  4. 4Catatonia and the Neuroleptic Malignant Syndrome – a Single Entity?1992 · 134 citations
  5. 5Catatonia as a risk factor for the development of neuroleptic malignant syndrome: Report of a case following treatment with clozapine2008 · 36 citations