What question did this study set out to answer?

To review the pathophysiological mechanisms contributing to sepsis-induced myocardial dysfunction and evaluate current and emerging clinical management strategies.

March 21, 2016Journal of Intensive CareOpen Access

Sepsis-induced myocardial dysfunction: pathophysiology and management

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Authors

YKYasuyuki KakihanaKagoshima University TITakashi ItoKumamoto University MNMayumi NakaharaUniversity of Miyazaki Hospital

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Implication

Review delineates mechanisms of sepsis-induced myocardial dysfunction in septic shock, highlighting the need to balance infection control and fluid resuscitation.

Key Points

To review the pathophysiological mechanisms contributing to sepsis-induced myocardial dysfunction and evaluate current and emerging clinical management strategies.
Synthesized molecular, clinical, and physiological evidence concerning myocardial depression and diastolic dysfunction in severe sepsis.
Assessed the pathological roles of microbial triggers, endogenous inflammatory mediators, and interventions including fluid resuscitation, vasopressors, and inotropic agents.
Pathogen-associated molecular patterns, nitric oxide, cytokines, and damage-associated molecular patterns—specifically extracellular histones and HMGB1—perpetuate myocardial depression through a self-amplifying inflammatory cascade.
Optimal management requires early antimicrobial administration to control pathogen-derived triggers, coupled with judicious fluid and hemodynamic support to avoid catecholamine toxicity and volume overload.

Cite This Study

Kakihana et al. (2016) studied this question.

synapsesocial.com/papers/696fa533cf08ece81932e5d4 https://doi.org/10.1186/s40560-016-0148-1

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Implication

Review delineates mechanisms of sepsis-induced myocardial dysfunction in septic shock, highlighting the need to balance infection control and fluid resuscitation.

Sepsis-induced myocardial dysfunction: pathophysiology and management

Discussion

Member takes

Implication

Key Points

Cite This Study

Sepsis-induced myocardial dysfunction: pathophysiology and management

Discussion

Member takes

Implication

Key Points

Cite This Study

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