Multi-step mechanisms of early phospholipid hydrolysis and mineralisation unveiled through combined quantum chemical calculations and experimental analysis

Key Points

• This research aims to uncover the mechanisms of phospholipid hydrolysis and its role in mineralisation during bone formation.
• Utilized quantum chemical calculations to explore molecular interactions.
• Conducted experimental analysis to observe mineralisation rates of different phospholipids.
• Compared the effects of phosphatidylserine and phosphatidylcholine on bone mineralisation.
• Phosphatidylserine induced faster mineralisation compared to phosphatidylcholine.
• Identified distinct molecular mechanisms involved in phospholipid hydrolysis.
• Highlighted the pivotal role of phospholipids in early bone formation processes.