Multi-step mechanisms of early phospholipid hydrolysis and mineralisation unveiled through combined quantum chemical calculations and experimental analysis

Keisuke Shibata; Takahumi Shiotani; Y. Chen; Reina Kurihara; Katsunori Yamaguchi; Emilio Satoshi Hara; Nílson Kunioshi

doi:10.1039/d5tb01744k

January 1, 2026Journal of Materials Chemistry BOpen Access

Multi-step mechanisms of early phospholipid hydrolysis and mineralisation unveiled through combined quantum chemical calculations and experimental analysis

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Key Points

This research aims to uncover the mechanisms of phospholipid hydrolysis and its role in mineralisation during bone formation.
Utilized quantum chemical calculations to explore molecular interactions.
Conducted experimental analysis to observe mineralisation rates of different phospholipids.
Compared the effects of phosphatidylserine and phosphatidylcholine on bone mineralisation.
Phosphatidylserine induced faster mineralisation compared to phosphatidylcholine.
Identified distinct molecular mechanisms involved in phospholipid hydrolysis.
Highlighted the pivotal role of phospholipids in early bone formation processes.

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Implication

Experimental and quantum chemical analysis reveals mechanisms behind phospholipid-induced mineralisation in bone formation.

Abstract

Phospholipids play key roles in bone formation, with phosphatidylserine (PS) reportedly inducing more rapid mineralisation than phosphatidylcholine (PC); however, the underlying mechanisms remains unclear.

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Cite This Study

Shibata et al. (2026) studied this question.

synapsesocial.com/papers/69706c09b6488063ad5c1841 https://doi.org/10.1039/d5tb01744k

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Multi-step mechanisms of early phospholipid hydrolysis and mineralisation unveiled through combined quantum chemical calculations and experimental analysis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Multi-step mechanisms of early phospholipid hydrolysis and mineralisation unveiled through combined quantum chemical calculations and experimental analysis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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