Observations demonstrate long-term effects on DNA methylation in men after in-utero exposure to dioxin, indicating potential health risks.
These observations are the first in the literature and align with the long-term semen quality reduction and alteration of thyroid homeostasic mechanisms reported in children exposed in utero to dioxin in Seveso. The actual dioxin background serum levels, 1.0-2.0 ppt, are much lower than those associated to these effects.
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Sacco et al. (2026) studied this question.
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