IGF2BP3 Enhances GSDMD Stability and Blocks JNK Signaling Activation to Promote Eyelid Basal Cell Carcinoma Pyroptosis in an m6A-Dependent Manner

Key Points

• To investigate the role of IGF2BP3 in enhancing GSDMD stability and blocking JNK signaling to promote pyroptosis in eyelid basal cell carcinoma.
• Analyzed the effect of IGF2BP3 on GSDMD stabilization.
• Examined the role of JNK signaling in eyelid basal cell carcinoma.
• Utilized m6A modulation to explore stability mechanisms.
• IGF2BP3 significantly enhances GSDMD stability.
• JNK signaling activation is effectively blocked by IGF2BP3.
• Promotion of pyroptosis in eyelid basal cell carcinoma was confirmed to be m6A-dependent.