A bio-inspired environmentally friendly and cost-effective chemo-enzymatic synthesis of (−)-ambrox from trans -nerolidol

Key Points

• The central aim is to develop a cost-effective and environmentally friendly method for synthesizing (−)-ambrox from trans-nerolidol.
• Utilized a chemo-enzymatic synthetic route
• Biosynthesis conducted in Saccharomyces cerevisiae
• Employed trans-nerolidol as the initial material
• Achieved a synthesis titre of 26.4 g L−1 of (−)-ambrox
• Showed effectiveness of the environmentally friendly approach
• Demonstrated bio-inspired techniques in synthesis