Case report reveals high-grade glioma detection in an atypical parkinsonism presentation, indicating diagnostic potential.
A 72-year-old man presented with right-sided rigidity and bradykinesia, but the history and neurological examination were not entirely compatible with degenerative parkinsonism. Initial MRI showed T2/FLAIR hyperintensity within the splenium, attributed to small vessel disease. Subsequent 18 F-FDOPA brain PET/MRI ruled out degenerative parkinsonism, but revealed avid tracer uptake (SUVmax 4.46) in the splenium corresponding to signal abnormality on structural imaging. This unexpected finding prompted contrast-enhanced MRI brain, which identified a peripherally enhancing splenium lesion concerning for neoplasm. Stereotactic biopsy confirmed GFAP-positive, diffuse high-grade glioblastoma, IDH-wildtype, WHO Grade 4, highlighting the role of FDOPA PET in the assessment of primary brain tumors.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: